Search results for "reference [key words]"
showing 10 items of 328 documents
Development of standard operation procedures for the manufacture of n-octadecyl bonded silicas as packing material in certified reference columns for…
2004
The development of standard operation procedures for the manufacture of a n-octadecyl bonded spherical silica packing from partially condensed tetraethoxysilane as silica source is described. The synthesis comprises five intermediate products and six synthesis steps which were examined according to their reproducibility and robustness. The results led to the optimisation of the manufacturing process for a n-octadecyl bonded silica. Correlations were drawn between the dynamic viscosity of the poly(ethoxy)siloxane (PES), the synthesis parameters, the resulting pore structural properties and particle size distribution of the silicas. Validated procedures were developed to manufacture spherical…
Identification of diterpenes in canvas painting varnishes by gas chromatography-mass spectrometry with combined derivatisation.
2004
A derivatisation method that combines the formation of ethyl esters from the carboxylic groups and trimethylsilyl ethers from hydroxyl groups of the components of diterpenic resins is presented in this paper. This methodology involves two experimental steps: (1) formation of ethyl esters using ethyl chloroformate; and (2) the esterified compounds are lead to react with trimethylsilylimidazole to form the corresponding trimethylsilyl ethers. The main advantage of the proposed method is the possibility of performing simultaneously the analysis of amino acids from proteins, fatty acids from drying oils, and diterpenic compounds from natural resins usually found in works of art. This methodolog…
Influence of oscillating main flow on separation efficiency in asymmetrical flow field-flow fractionation.
2021
The steadily rising interest in the investigation of interactions between nanomaterials and biological media has also led to an increasing interest in asymmetrical flow field-flow fractionation (AF-FFF). The biggest strength of AF-FFF is the possibility to alter the flow profiles to suit a specific separation problem. In this paper, the influence of an oscillating main flow on the separation efficiency of AF-FFF is investigated. Such oscillations can e.g. be caused by the main pump To investigate the influence of such flow conditions on the separation efficiency in AF-FFF systematically, different oscillation profiles were applied and their influence on the elution profile and the retention…
Rapid and simultaneous high-performance liquid chromatography assay of polyamines and monoacetylpolyamines in biological specimens
2000
A rapid, resolutive and reproducible reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed for polyamines and acetylpolyamines by adopting pre-column derivatization with benzoyl chloride. In a single run lasting less than 15 min ten polyamines were separated as well as traces of benzoic acid, methylbenzoate and benzoic anhydride. These contaminants, produced during the derivatization reaction, were almost all eliminated by washing steps envisaged in the same procedure. This simple and sensitive method can be applied to routine determination of polyamines in biological samples. A fine application of this procedure to the determination of endogenous content of p…
Validating retinal fundus image analysis algorithms: issues and a proposal.
2013
This paper concerns the validation of automatic retinal image analysis (ARIA) algorithms. For reasons of space and consistency, we concentrate on the validation of algorithms processing color fundus camera images, currently the largest section of the ARIA literature. We sketch the context (imaging instruments and target tasks) of ARIA validation, summarizing the main image analysis and validation techniques. We then present a list of recommendations focusing on the creation of large repositories of test data created by international consortia, easily accessible via moderated Web sites, including multicenter annotations by multiple experts, specific to clinical tasks, and capable of running …
Projection Clustering Unfolding: A New Algorithm for Clustering Individuals or Items in a Preference Matrix
2020
In the framework of preference rankings, the interest can lie in clustering individuals or items in order to reduce the complexity of the preference space for an easier interpretation of collected data. The last years have seen a remarkable flowering of works about the use of decision tree for clustering preference vectors. As a matter of fact, decision trees are useful and intuitive, but they are very unstable: small perturbations bring big changes. This is the reason why it could be necessary to use more stable procedures in order to clustering ranking data. In this work, a Projection Clustering Unfolding (PCU) algorithm for preference data will be proposed in order to extract useful info…
Further improvements of the water-cooled Pb–17Li blanket
2001
Abstract The water-cooled lithium–lead (WCLL) blanket is based on reduced-activation ferritic–martensitic steel as the structural material, the liquid alloy Pb–17Li as breeder and neutron multiplier, and water at typical PWR conditions as coolant. It was developed for DEMO specifications and shall be tested in ITER. In 1999, a reactor parameter optimization was performed in the EU which yielded improved specifications of what could be an attractive fusion power plant. Compared to DEMO, such a power reactor would be different in lay-out, size and performance, thus requiring to better exploit the potential of the WCLL blanket concept in conjunction with a water-cooled divertor. Several new ap…
Clinically-Driven Virtual Patient Cohorts Generation: An Application to Aorta
2021
The combination of machine learning methods together with computational modeling and simulation of the cardiovascular system brings the possibility of obtaining very valuable information about new therapies or clinical devices through in-silico experiments. However, the application of machine learning methods demands access to large cohorts of patients. As an alternative to medical data acquisition and processing, which often requires some degree of manual intervention, the generation of virtual cohorts made of synthetic patients can be automated. However, the generation of a synthetic sample can still be computationally demanding to guarantee that it is clinically meaningful and that it re…
Dog-bite-related attacks: A new forensic approach
2020
Dog attacks today represent a health hazard considering that prevention strategies have not always been successful. The identification of the dog that attacked the victim is necessary, considering the civil or criminal consequences for the animal's owner. An accurate scene analysis must be performed collecting a series of important information.Forensic investigations in dog attacks involve different methods, such as the evaluating of the canine Short Tandem Repeat (STR) typing in saliva traces on wounds or bite mark analysis, however, these techniques cannot always be applied. The effort to find new methods to identify the dog that attacked the victim represents a very interesting field for…
Key EU DEMO plant and building layout criteria
2021
Abstract An early attention to the layout of both plant site and its buildings is essential in a complex plant under preliminary design as DEMO in order to meet the assigned targets, namely i) the licensing requirements ii) a good availability in delivery electricity to the grid. The layout definition has to follow several criteria that become more complex and stringent for nuclear buildings, e.g. functional, maintenance, fire protection, safety, human factors, shielding, and remote handling. The criterion As Low As Reasonable Achievable, with respect to the dose to the staff, has to be applied in design, operation, maintenance and decommissioning phases. The tokamak building, where several…